Ideation and Implementation of an Open Science Drug Discovery Business Model
M4K Pharma was incorporated to launch an open science drug discovery program that relies on regulatory exclusivity as its primary intellectual property and commercial asset, in lieu of patents. In many cases and in key markets, using regulatory exclusivity can provide equivalent commercial protection to patents, while also being compatible with open science. The model is proving attractive to government, foundation and individual funders, who collectively have different expectations for returns on investment compared with biotech, pharmaceutical companies, or venture capital investors.In the absence of these investor-driven requirements for returns, it should be possible to commercialize therapeutics at affordable prices. M4K is piloting this open science business model in a rare paediatric brain tumour, but there is no reason it should not be more widely applicable.
University of California Challenges Elsevier over Access to Scholarly Research
University of California System is playing hardball with Elsevier in negotiations that could transform the way it pays to read and publish research. But does the UC system have the clout to pull it off?
In the 21st Century, research is increasingly data- and computation-driven. Researchers, funders, and the larger community today emphasize the traits of openness and reproducibility. In March 2017, 13 mostly early-career research leaders who are building their careers around these traits came together with ten university leaders (presidents, vice presidents, and vice provosts), representatives from four funding agencies, and eleven organizers and other stakeholders in an NIH- and NSF-funded one-day, invitation-only workshop titled “Imagining Tomorrow’s University.” Workshop attendees were charged with launching a new dialog around open research – the current status, opportunities for advancement, and challenges that limit sharing.
The workshop examined how the internet-enabled research world has changed, and how universities need to change to adapt commensurately, aiming to understand how universities can and should make themselves competitive and attract the best students, staff, and faculty in this new world. During the workshop, the participants re-imagined scholarship, education, and institutions for an open, networked era, to uncover new opportunities for universities to create value and serve society. They expressed the results of these deliberations as a set of 22 principles of tomorrow's university across six areas: credit and attribution, communities, outreach and engagement, education, preservation and reproducibility, and technologies.
Springer Nature and Publons Enter Wide-ranging Partnership to Bring Greater Efficiency and Recognition to Peer Review
The burden on the peer review community is increasing as the volume of published research articles grows. Research output is rising exponentially and this is putting pressure on the system, with many academics inundated with requests to peer review. The recent Global State of Peer Review report highlights a growing “reviewer fatigue”.To help address this, Springer Nature and Publons, part of Clarivate Analytics, have announced a partnership to improve the peer review process and enable peer reviewers to receive recognition for their contribution.
Changing Demographics of Scientific Careers: The Rise of the Temporary Workforce
Contemporary science has been characterized by an exponential growth in publications and a rise of team science. At the same time, there has been an increase in the number of awarded PhD degrees, which has not been accompanied by a similar expansion in the number of academic positions.
Scientific Prize Network Predicts Who Pushes the Boundaries of Science
Scientific prizes confer credibility to persons, ideas, and disciplines, provide financial incentives, and promote community-building celebrations. The authors examine the growth dynamics and interlocking relationships found in the worldwide scientific prize network. They focus on understanding how the knowledge linkages among prizes and scientists' propensities for prizewinning relate to knowledge pathways between disciplines and stratification within disciplines. Their data cover more than 3,000 different scientific prizes in diverse disciplines and the career histories of 10,455 prizewinners worldwide for over 100 years. They find several key links between prizes and scientific advances. First, despite an explosive proliferation of prizes over time and across the globe, prizes are more concentrated within a relatively small group of scientific elites, and ties among elites are highly clustered, suggesting that a relatively constrained number of ideas and scholars push the boundaries of science. For example, 64.1% of prizewinners have won two prizes and 13.7% have won five or more prizes. Second, certain prizes strongly interlock disciplines and subdisciplines, creating key pathways by which knowledge spreads and is recognized across science. Third, genealogical and coauthorship networks predict who wins multiple prizes, which helps to explain the interconnectedness among celebrated scientists and their pathbreaking ideas.
In academia, assessment of grant proposals is the forward‐looking review, the laying out and checking of your research plan, while peer reviews in journals are the final, consolidatory scrutiny before publication. An important difference between these academic checkpoints and my, admittedly somewhat forced fashionista analogy, is that in academia the two stages of review take place independently of each other.