Associations Between Industry Involvement and Study Characteristics at the Time of Trial Registration in Biomedical Research
Study investigates whether industry involvement in biomedical research affects trial design. A reduced use of active controls (such as alternate treatment or standard care) was found in trials with industry involvement, which can have the side effect of making results look more favourable than they actually are.
RoB 2: a Revised Tool for Assessing Risk of Bias in Randomised Trials
Assessment of risk of bias is regarded as an essential component of a systematic review on the effects of an intervention. The most commonly used tool for randomised trials is the Cochrane risk-of-bias tool. We updated the tool to respond to developments in understanding how bias arises in randomised trials, and to address user feedback on and limitations of the original tool.