A century and a half has seen momentous changes in science. But evidence and transparency are more important than ever before.

With better questions, many reproducibility problems will fall away, says Paul Smaldino.

Container platforms let researchers run each other's software - and check the results.

Can science continue to fulfil its social contract and to reach new horizons by advancing on the same footing into the future? Or does something need to shift?

From all too scarce, to professionalized, the ethics of research is now everybody's business, argues Sarah Franklin.

Students must learn that a doctoral degree isn't for everyone - and that not doing one might be a better option.

Peer review process helps funders make decisions, but researchers say it is lacks transparency and takes up too much of their time.

Abhijit Banerjee, Esther Duflo and Michael Kremer have been awarded the prize for their experimental approach to alleviating poverty.

Biological advances have repeatedly changed who we think we are.

Readers say they have been asked to reference seemingly superfluous studies after peer review.

Organs-on-a-chip and other technologies are becoming reliable models for testing drug efficacy and toxicity.

The Pulitzer prizewinner shares his advice for pleasing readers, editors and yourself.

Besieged Iranian researchers say that currency collapse, scientific isolation and psychological strain are hindering almost every aspect of their work.