Addressing the most pressing contemporary social, environmental, and technological challenges will require integrating insights and sharing data across disciplines, geographies, and cultures. Strengthening international data sharing networks will not only demand advancing technical, legal, and logistical infrastructure for publishing data in open, accessible formats; it will also require recognizing, respecting, and learning to work across diverse data cultures. This essay introduces a heuristic for pursuing richer characterizations of the “data cultures” at play in international, interdisciplinary data sharing.