In this massively data rich world, the equilibrium between information and knowledge has increasingly shifted from knowledge toward information. Advanced text and data mining (TDM) is not yet ubiquitous and even if it were, not all content is structured enough to leverage TDM potential. In developing the supercomputer Watson with the ability to process, analyze and extract information from natural language such as PLOS article text, IBM is beginning to shift the equilibrium back to knowledge. Understanding Relationships PLOS and IBM Watson are collaborating to bring quality Open Access biomedical literature to healthcare entrepreneurs and innovators, and to do so in a way that provides full article content and context including PubMed citation information from the National Library of Medicine. The collaboration is “not just about PLOS or Open Access,” says PLOS Chief Technology Officer CJ Rayhill, “it’s about improved healthcare through immediate access to relevant clinical,